Wolber et al. created multiple pharmacophore models based on the protein crystal structures of STI-571 and its homologues (1iep, 1fpu, 1opj). The LigandScout software was then used to merge the pharmacophore models. As shown in the figure below, the resulting pharmacophore model contains 4 hydrophobic aromatic groups, 2 aliphatic hydrophobic groups, 2 hydrogen bond donor groups, 1 hydrogen bond acceptor group, and 8 repulsion groups volume group. Receptor-based Pharmacophore Model https://www.computabio.com/receptor-based-pharmacophore-model-service.html
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