CAS No:19916-73-5
Formula:C12H11N5O
Synonyms:6-Benzyloxy Guanine;2-amino-6-benzyloxypurine;6-(benzyloxy)-7H-purin-2-amine;6-O-Benzylguanine;
China Export:From 2018.11 to 2019.11, total export volume of 6-Benzyloxy guanine from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.
Echemi Chemical 6-Benzyloxy guanine Description
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity[1][2].
Echemi Chemical 6-Benzyloxy guanine Basic Attributes
CAS No:19916-73-5
Molecular Formula :C12H11N5O
Molecular Mass :241.25
Exact Mass :241.096359
PSA :89.7 A^2
LogP :1.2
EINECS :1592732-453-0
InChIKeys :KRWMERLEINMZFT-UHFFFAOYSA-N
H-bond Acceptor :5
H-bond Donor :2
SP3 :0.08
RBN :3
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