In situ hybridization is a technique for detecting the expression pattern of a particular gene sequence in cells or tissues using a complimentary sequence known as a probe. The probe is typically labeled with a fluorochrome or an enzyme, so it can be detected either by using a fluorescent microscope or with a bright field microscope. RNA in situ hybridization https://www.histobiolab.com/in-situ-hybridization-ish.html