Tissue plasminogen activator (tPA). The product is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. Tissue plasminogen activator https://www.creativebiomart.net/therapeutic-proteins/p/20/tissue-plasminogen-activator-tpa/