creativebiolabs
3 years ago

"ADCC-Enhanced anti-AChR (P90-131) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform. By reducing the fucosylation of the Fc region, the ADCC-enhanced antibody shows an increased binding affinity for the FcyR receptor on immune effector cells. More specifically, the afucosylated therapeutic biobetter antibody was generated by recombinant DNA technology. It has been produced in CHO cells that are deficient for fucosylation and purified by affinity chromatography with protein G. The absence of the fucose residue from the N-glycans of IgG-Fc results in dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC)." ADCC-Enhanced anti-AChR biobetter https://adcc.creative-biolabs.com/adcc-enhanced-anti-achr-biobetter-1021.htm